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The proto-oncogene c-Kit is expressed in a subpopulation of normal cutaneous melanocytes. The receptor tyrosine kinase encoded by the c-Kit proto-oncogene mediates mitogenic signaling by stem cell factor, and its activation is involved in the development and maintenance of some hematopoietic cells. A Merkel cell carcinoma (MCC) is a primary, rapidly growing, typically aggressive skin carcinoma with a distinct histopathological and immunohistochemical phenotype and with a 30% 2-year survival rate. To date, no significant progress has been made in the treatment of MCC. Many clinical trials are still being performed. Almost all patients with MCC have been reported to express the c-Kit receptor tyrosine kinase. Additionally, some other tyrosine kinase receptors, such as KIT, PDGFRA, PDGFRB, AXL and FLT3 are involved in the pathogenesis of human MCC. There is evidence that c-Kit inhibitors could prevent tumor growth. In this study we aimed to investigate the expression of c-Kit in MCC with two different commercial monoclonal antibodies (mAbs) using immunohistochemistry on tissue microarrays. We found that almost all cases of MCCs express c-Kit. Moreover, there is a significant correlation between the immunoreactivity with these two different mAbs in the case of c-Kit receptor
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Global Mapper 12 Crack
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