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What are the pathways in blood?

Are there any fibrous, re-occurring structures in blood which can be specifically bound by drugs to reduce their effectiveness in the body?
For example: If we bind with a drug, specifically, how do the tiny kidneys get rid of excess drug bound to blood? What are the pathways in blood?

A:

You are asking about the effects of drug metabolism by means of enzymes and metabolism by, more specifically, Phase I and Phase II enzymes.

Drug metabolism is the process by which a drug or its metabolites are inactivated or excreted from the body. Two major pathways exist in Phase I metabolism. For the majority of drugs, a single oxidative pathway occurs when a drug is converted to a metabolite that is more polar, with a decreased lipophilicity. In these cases, the metabolite is excreted from the body. The other pathway consists of conjugation, where a drug is chemically modified by conjugation of an exogenous substance such as a glucuronide.
Drug metabolism by Phase II enzymes or conjugation is not directly related to drug toxicity. It is the major pathway for the excretion of many drugs, including: drug glucuronides, drug sulfates, and others.

From
Blood does not contain fibrous structures. (As an aside, this is a layperson’s question, and you can find the answer in a biochemistry textbook or simply Google it.)

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