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Hello, my name is Alisher Khamidulin. I have been working in IT for the past 5 years, including security of networks, wireless installation, IP telephony, network automation, graphic designing and development, etc. I can write in Russian, English, and Uzbek, and I’ve also worked in localization.Heparin is widely used therapeutically for its various biological activities. Among these activities are coagulation regulation, inhibition of complement activation, regulation of inflammation, inhibition of the activity of thrombin and tissue plasminogen activator (TPA), prevention of tumor cell metastasis, immunostimulation, and inhibition of platelet aggregation. For these reasons, heparin, as well as other heparin preparations, is used clinically for anticoagulation, anti-complementary, anti-inflammatory, anti-thrombotic, antiproliferative, anti-tumor, and immunostimulatory applications.
The inherent anticoagulant activity of heparin, in addition to its known antithrombotic properties, is attributable, at least in part, to inhibition of thrombin, factor Xa and the enzyme tissue plasminogen activator (TPA). Heparin inhibits the binding of thrombin and/or factor Xa to fibrinogen and inhibits thrombin from converting fibrinogen to fibrin. Tissue plasminogen activator (TPA) is a proteolytic enzyme that catalyzes the conversion of plasminogen to plasmin. Plasmin is an activator of soluble plasma protease inhibitors and is thus thought to maintain the antiplasmolytic properties of antithrombin III, alpha-2-macroglobulin, and alpha-1-proteinase inhibitor. Tissue plasminogen activator is also known to be involved in the conversion of plasminogen to plasmin, thus increasing the degradation of fibrin in the blood. Heparin inhibits TPA activity and hence the conversion of plasminogen to plasmin.
In vivo, heparin inhibits coagulation via a cofactor