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All the NCERT Solutions for Maths are available in PDF format which can be downloaded by the students easily .Cancers are characterized by uncontrolled cell proliferation. The genes responsible for cell cycle regulation have key roles in the development of cancer. For example, the Cyclin Ds and their associated kinases, Cyclin-dependent Kinase 4 and 6 (CDK4, 6) play a crucial role in the regulation of cell cycle checkpoints.
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CDK6 is also known to interact with Cyclin Ds to phosphorylate retinoblastoma protein (pRb). In addition, it was demonstrated that CDK6 activity is regulated by phosphorylation which occurs at a threonine residue in the C-terminal domain. Mutations in this threonine residue are seen in several different cancers, suggesting that this may have a role in the development of cancer.
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There are several problems with this strategy. First, the activity of CDK4/6 is dependent on complexes with Cyclin Ds, and multiple Cyclin Ds can associate with a single CDK4/6. Many cancers therefore contain multiple isoforms of Cyclin D and CDK4/6. Second, although CDK4/6 is specifically required for the G1 to S transition, it cannot discriminate between Cyclin D
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